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British Journal of Anaesthesia, Vol 84, Issue 3 401-402, Copyright © 2000 by Oxford University Press

ARTICLES

Caudal clonidine for postoperative analgesia in adults

AC Van Elstraete, F Pastureau, T Lebrun and H Mehdaoui
Department of Anaesthesiology, Saint-Paul Medical Center, Fort-de- France, Martinique, France.

We have assessed the analgesic efficacy and side effects of caudally administered clonidine in a prospective, randomized, double-blind, placebo-controlled study. We studied 64 adult patients undergoing elective haemorrhoidectomy. Caudal block was performed in all patients using a mixture of 0.5% bupivacaine 35 mg with 2% lidocaine 140 mg and epinephrine 5 micrograms ml-1. Patients were allocated randomly to one of two groups. Clonidine 75 micrograms was added in group C and saline 1 ml in group S. Median time to first analgesic requirements was significantly longer in group C (mean 729 (SD 120) min) than in group S (276 (131) min) (P = 0.01). Bradycardia occurred in seven patients in group C but did not affect mean arterial pressure.
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