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British Journal of Anaesthesia, Vol 84, Issue 2 239-241, Copyright © 2000 by Oxford University Press


ARTICLES

Use of microalbuminuria as a predictor of outcome in critically ill patients

KL MacKinnon, Z Molnar, D Lowe, ID Watson and E Shearer
Department of Clinical Biochemistry, University Hospital Aintree, Liverpool, UK.

We have investigated the use of microalbuminuria as a predictor of outcome in a pilot study involving 50 critically ill patients in a six- bed hospital intensive care unit (ICU). Urinary microalbumin:creatinine (M:Cr) ratios measured only 6 h after admission to the ICU demonstrated a significant difference (P = 0.01) between survivors and non- survivors, allowing rapid identification of patients at increased risk of developing organ failure and at greater risk of death. This work suggests that earlier identification of these patients using a rapid, simple, inexpensive biochemical test is possible; if confirmed in a larger study, it may be that clinical interventions can be targeted at those most likely to benefit.
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