British Journal of Anaesthesia, Vol 84, Issue 2 226-235, Copyright © 2000 by Oxford University Press
JG Jones and CA Wardrop
Clinical studies to assess the benefits of blood transfusion or
haemodilution in critical illness should take account of measured CBV
before, during and after intervention. As mentioned above, surrogate
measures of CBV are inadequate and studies based on these must be
considered incomplete, because they cannot distinguish between effects of
changes in haemoglobin concentration and changes in blood volume. The
choice of a suitable technique for measuring CBV depends on the facilities
available locally. In general, methods based on labelled red cells are more
reliable but are technically demanding and time consuming. Those based on
albumin are likely to yield false high values and this is particularly true
in all patients with impaired capillary integrity. The most promising
plasma marker is hydroxyethyl starch which may be particularly useful when
the polysaccharide is labelled with a fluorescent dye. Attaching
fluorescein to hydroxyethyl starch is not difficult and, should demand be
sufficient, it may well become available from manufacturers who are already
capable of providing other fluorescent polysaccharides. The clinical
benefits of such a development would include more rational schedules of
i.v. fluid and blood transfusion management in surgical and intensive care
patients.
ARTICLES
Measurement of blood volume in surgical and intensive care practice
School of Biological Sciences, Cardiff University, UK.
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