British Journal of Anaesthesia, Vol 84, Issue 2 215-220, Copyright © 2000 by Oxford University Press
H Tsuchida, S Seki, S Tanaka, K Okazaki and A Namiki
Isolated spiral strips of rat thoracic aorta with endothelium were
suspended for isometric tension recordings in a physiological salt
solution. Endothelium-dependent vasorelaxation was elicited by carbachol
10(-6) and 10(-5) mol litre-1 during norepinephrine-induced contractions,
and the effects of 1.5% and 3% halothane were evaluated with concomitant
measurement of [Ca2+]i using fura-2-Ca2+ fluorescence. The effects of
halothane on endothelium-dependent relaxation were compared with those of
nitro G-L-arginine methyl ester 10(-4) mol litre- 1 (L-NAME: an inhibitor
of nitric oxide synthase). Carbachol reduced norepinephrine-induced
contractions in a concentration-dependent manner, but augmented the
norepinephrine-induced increase in [Ca2+]i in endothelium intact strips. In
contrast, carbachol did not influence muscle tension or [Ca2+]i when the
endothelium was completely denuded. Although 3% halothane and L-NAME 10(-4)
mol litre-1 inhibited carbachol- induced vasorelaxation in a similar
manner, halothane inhibited carbachol-induced increases in [Ca2+]i. These
results indicate that halothane inhibited a carbachol-induced increase in
[Ca2+]i in the endothelium, which subsequently attenuated the decrease in
muscle tension.
ARTICLES
Halothane attenuates the endothelial Ca2+ increase and vasorelaxation of vascular smooth muscle in the rat aorta
Department of Anaesthesiology, Sapporo Medical University School of Medicine, Japan.
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