British Journal of Anaesthesia, Vol 84, Issue 2 204-214, Copyright © 2000 by Oxford University Press
R Kato, S Ross and P Foex
We have investigated if fentanyl protects against myocardial ischaemic
injury and if so, if the mechanism of this protection is mediated via
opioid and adenosine A1 receptors, and KATP channels. Langendorff rat
hearts were subjected to global ischaemia (30 min) and reperfusion (60
min). The drugs were administered before induction of ischaemia and
maintained throughout the experiment. Treatment with fentanyl 740 nmol
litre-1 improved post-ischaemic mechanical function, assessed as developed
pressure, +dP/dtmax and -dP/dtmin, compared with controls after 60 min of
reperfusion. These effects were abolished by naloxone 1 mumol litre-1,
DPCPX 10 mumol litre-1, a selective adenosine A1 antagonist and sodium
5-hydroxydecanoate 100 mumol litre-1, a K+ATP channel blocker. We conclude
that fentanyl protected the heart against post-ischaemic injury by a
mechanism which was blocked by an opioid and an adenosine A1 receptor
antagonist and also by a KATP channel antagonist.
ARTICLES
Fentanyl protects the heart against ischaemic injury via opioid receptors, adenosine A1 receptors and KATP channel linked mechanisms in rats
Nuffield Department of Anaesthetics, Radcliffe Infirmary, Oxford, UK.
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