British Journal of Anaesthesia, Vol 84, Issue 2 197-203, Copyright © 2000 by Oxford University Press
WA Mutch, GM Eschun, SE Kowalski, MR Graham, LG Girling and GR Lefevre
We have studied the time course of changes in gas exchange and respiratory
mechanics using two different modes of ventilation during 7 h of isoflurane
anaesthesia in pigs. One group received conventional control mode
ventilation (CV). The other group received biologically variable
ventilation (BVV) which simulates the breath-to-breath variation in
ventilatory frequency (f) that characterizes normal spontaneous
ventilation. After baseline measurements with CV, animals were allocated
randomly to either CV or BVV (FIO2 1.0 with 1.5% end- tidal isoflurane).
With BVV, there were 376 changes in f and tidal volume (VT) over 25.1 min.
Ventilation was continued over the next 7 h and blood gases and respiratory
mechanics were measured every 60 min. The modulation file used to control
the ventilator for BVV used an inverse power law frequency distribution
(I/fa with a = 2.3 +/- 0.3). After 7 h, at a similar delivered minute
ventilation, significantly greater PaO2 (mean 72.3 (SD 4.0) vs 63.5 (6.5)
kPa) and respiratory system compliance (1.08 (0.08) vs 0.92 (0.16) ml cm
H2O-1 kg-1) and lower PaCO2 (6.5 (0.7) vs 8.7 (1.5) kPa) and shunt fraction
(7.2 (2.7)% vs 12.3 (6.2)%) were seen with BVV, with no significant
difference in peak airway pressure (16.3 (1.2) vs 15.3 (3.7) cm H2O). A
deterioration in gas exchange and respiratory mechanics was seen with
conventional control mode ventilation but not with BVV in this experimental
model of prolonged anaesthesia.
ARTICLES
Biologically variable ventilation prevents deterioration of gas exchange during prolonged anaesthesia
Department of Anaesthesia, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  N. Soni and P. Williams Positive pressure ventilation: what is the real cost? Br. J. Anaesth., October 1, 2008; 101(4): 446 - 457. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Thammanomai, L. E. Hueser, A. Majumdar, E. Bartolak-Suki, and B. Suki Design of a new variable-ventilation method optimized for lung recruitment in mice J Appl Physiol, May 1, 2008; 104(5): 1329 - 1340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. B. Drummond and J. Milic-Emili Forty years of closing volume Br. J. Anaesth., December 1, 2007; 99(6): 772 - 774. [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Pillow, N. Hillman, T. J. M. Moss, G. Polglase, G. Bold, C. Beaumont, M. Ikegami, and A. H. Jobe Bubble Continuous Positive Airway Pressure Enhances Lung Volume and Gas Exchange in Preterm Lambs Am. J. Respir. Crit. Care Med., July 1, 2007; 176(1): 63 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Graham, R. K. Warrian, L. G. Girling, L. Doiron, G. R. Lefevre, M. Cheang, and W. A. C. Mutch Fractal or biologically variable delivery of cardioplegic solution prevents diastolic dysfunction after cardiopulmonary bypass J. Thorac. Cardiovasc. Surg., January 1, 2002; 123(1): 63 - 71. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. C. Mutch, G. R. Lefevre, M. S. Cheang, B. A. Simon, R. G. Brower, H. E. Fessler, C. A. Rohde, and A. J. Nam BIOLOGIC VARIABILITY IN MECHANICAL VENTILATION IN A CANINE OLEIC ACID LUNG INJURY MODEL Am. J. Respir. Crit. Care Med., June 1, 2001; 163(7): 1756 - 1757. [Full Text] [PDF]
|
|
|
|
|
|
W. A. C. MUTCH, S. HARMS, M. RUTH GRAHAM, S. E. KOWALSKI, L. G. GIRLING, and G. R. LEFEVRE Biologically Variable or Naturally Noisy Mechanical Ventilation Recruits Atelectatic Lung Am. J. Respir. Crit. Care Med., July 1, 2000; 162(1): 319 - 323. [Abstract] [Full Text]
|
|