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British Journal of Anaesthesia, Vol 84, Issue 1 97-99, Copyright © 2000 by Oxford University Press

ARTICLES

Analgesic action of i.v. morphine-6-glucuronide in healthy volunteers

TM Buetler, OH Wilder-Smith, CH Wilder-Smith, S Aebi, T Cerny and R Brenneisen
Department of Clinical Research, University of Bern, Switzerland.

The pharmacodynamics of morphine-6-glucuronide (M-6-G) i.v. were assessed in 12 healthy male volunteers in an open study. After a single bolus dose of M-6-G 5 mg i.v., we measured antinociceptive effects, using electrical and cold pain tests, and plasma concentrations of M-6- G, morphine-3-glucuronide (M-3-G) and morphine. Pain intensities during electrical stimulation (at 30, 60 and 90 min after injection) and ice water immersion (at 60 min) decreased significantly (P < 0.005) compared with baseline. Mean plasma peak concentrations of M-6-G were 139.3 (SD 38.9) ng ml-1, measured at 15 min. Our data demonstrate that M-6-G has significant analgesic activity.
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