British Journal of Anaesthesia, Vol 84, Issue 1 95-96, Copyright © 2000 by Oxford University Press
MG Serpell, E Anderson, D Wilson and N Dawson
Opioids administered to peripheral tissues can have significant analgesic
effects in doses which would not be effective centrally. We have assessed
the effects of regional diamorphine 2.5 mg i.v. in 14 patients undergoing
surgical correction of bilateral arthritic foot deformities in a
prospective, randomized, double-blind study. Patients acted as their own
controls as only one foot received the active drug. Visual analogue scale
(VAS) pain scores and wound tenderness were measured over 72 h. Diamorphine
did not improve median VAS area under the curve pain scores during the
first 6 h after surgery (33 (95% confidence intervals (CI) 25-46) vs 24
(17-35)). It also did not effect wound hypersensitivity when tested at 72 h
after surgery (95 (47-125) vs 90 (50-125) g). There were no significant
adverse effects.
ARTICLES
I.v. regional diamorphine for analgesia after foot surgery
Department of Anaesthesia, Western Infirmary, Glasgow, UK.
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