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British Journal of Anaesthesia, Vol 83, Issue 4 665-667, Copyright © 1999 by The Board of Management and Trustees of the British Journal of Anaesthesia

SHORT COMMUNICATIONS

Propofol anaesthesia in mice is potentiated by muscimol and reversed by bicuculline

M. Irifune, M. Sugimura, T. Takarada, K. Maeoka, Y. Shimizu, T. Dohi, T. Nishikawa and M. Kawahara
Department of Anaesthesiology and Department of Pharmacology, Hiroshima University School of Dentistry, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan; Department of Pharmacology, Kagoshima University Dental School, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan

We have examined the role of gamma-aminobutyric acid (GABA) neurones in propofol anaesthesia in mice using the righting reflex. Propofol i.p. increased the percentage of loss of the righting reflex in a dose- dependent manner with an ED50 value of 140 (95% confidence limits 123- 160) mg kg-1 (n = 40; eight animals per dose, five doses per dose- response curve). The ED50 for propofol decreased significantly to 66 (58-75) mg kg-1 in the presence of the GABAA receptor agonist muscimol 1 mg kg-1 i.p. (n = 40) (P < 0.05). In contrast, the ED50 increased significantly to 240 (211-274) mg kg-1 in the presence of the antagonist bicuculline 5 mg kg-1 i.p. (n = 40) (P < 0.05). Our results suggest that propofol anaesthesia may be mediated, at least in part by GABA neurons.
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