Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (22)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by De Lima, J.
Right arrow Articles by Fitzgerald, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by De Lima, J.
Right arrow Articles by Fitzgerald, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, Vol 83, Issue 4 662-664, Copyright © 1999 by The Board of Management and Trustees of the British Journal of Anaesthesia

SHORT COMMUNICATIONS

Sensory hyperinnervation after neonatal skin wounding: effect of bupivacaine sciatic nerve block

J. De Lima, D. Alvares, D. J. Hatch and M. Fitzgerald
Portex Department of Anaesthesia, Guilford Street, London WC1N 3EH, UK; Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK

The response to tissue injury includes sensitization of peripheral nociceptors and central neuronal pathways leading to acute clinical and inflammatory pain. A further response is sprouting of sensory nerve terminals in the region of skin damage. This hyperinnervation response is particularly intense in neonates compared with adults. In this study, we tested the effect of regional nerve block at the time of injury on skin hyperinnervation. Anaesthetized newborn rat pups were treated with percutaneous sciatic nerve block injections of 0.25% bupivacaine 25 microliters followed by a localized hindpaw skin wound. Cutaneous innervation was studied by image analysis of immunostained skin sections, 7 days after wounding, and sensory thresholds were assessed using von Frey hairs. The results showed that both hyperinnervation and hypersensitivity were not significantly altered by the application of a regional nerve block at the time of injury. This suggests that regional analgesia, used commonly in clinical practice, is unlikely to prevent the hyperinnervation that follows skin wounding.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 JAMAHome page
R. Carbajal, A. Rousset, C. Danan, S. Coquery, P. Nolent, S. Ducrocq, C. Saizou, A. Lapillonne, M. Granier, P. Durand, et al.
Epidemiology and Treatment of Painful Procedures in Neonates in Intensive Care Units
JAMA, July 2, 2008; 300(1): 60 - 70.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
K J S Anand and R W Hall
Pharmacological therapy for analgesia and sedation in the newborn.
Arch. Dis. Child. Fetal Neonatal Ed., November 1, 2006; 91(6): F448 - F453.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
D. G. Ririe, D. Barclay, H. Prout, C. Tong, J. R. Tobin, and J. C. Eisenach
Preoperative Sciatic Nerve Block Decreases Mechanical Allodynia More in Young Rats: Is Preemptive Analgesia Developmentally Modulated?
Anesth. Analg., July 1, 2004; 99(1): 140 - 145.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
R. F. Howard
Current Status of Pain Management in Children
JAMA, November 12, 2003; 290(18): 2464 - 2469.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C. Torsney and M. Fitzgerald
Spinal dorsal horn cell receptive field size is increased in adult rats following neonatal hindpaw skin injury
J. Physiol., July 1, 2003; 550(1): 255 - 261.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
M. Fitzgerald and S. Beggs
Book Review: The Neurobiology of Pain: Developmental Aspects
Neuroscientist, June 1, 2001; 7(3): 246 - 257.
[Abstract] [PDF]

Home page
 Anesth. Analg.Home page
C. Berde and B. Cairns
Developmental Pharmacology Across Species: Promise and Problems
Anesth. Analg., July 1, 2000; 91(1): 1 - 5.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.