British Journal of Anaesthesia, Vol 83, Issue 4 654-656, Copyright © 1999 by The Board of Management and Trustees of the British Journal of Anaesthesia
M. A. Shajar, J. P. Thompson, A. P. Hall, NAP. Leslie and A. J. Fox
We have examined the effect of remifentanil on the haemodynamic response to
emergence from anaesthesia and tracheal extubation in 40 ASA I-II female
patients undergoing diagnostic laparoscopy, in a randomized, double-blind
study. All patients received a standard general anaesthetic comprising
propofol, vecuronium and 1% isoflurane with 66% nitrous oxide in oxygen. At
the end of surgery, a bolus dose of remifentanil 1 microgram kg-1 (n = 20)
or saline placebo (n = 20) was given and tracheal extubation was performed
when standard criteria were achieved. Arterial pressure and heart rate were
recorded non- invasively at 1-min intervals from the end of surgery.
Remifentanil attenuated the increase in both mean arterial pressure (P <
0.001) and heart rate (P < 0.05) at extubation. Mean time to extubation
was 7.2 (SEM 0.6) min and 4.0 (0.5) min in the remifentanil and saline
groups, respectively (P < 0.001). There was no difference in the
incidence of coughing at extubation, time to recovery from anaesthesia or
time to fitness for discharge from the recovery room.
SHORT COMMUNICATIONS
Effect of a remifentanil bolus dose on the cardiovascular response to emergence from anaesthesia and tracheal extubation
University Department of Anaesthesia, Leicester Royal Infirmary, Leicester LE1 5WW, UK
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