British Journal of Anaesthesia, Vol 83, Issue 4 611-614, Copyright © 1999 by The Board of Management and Trustees of the British Journal of Anaesthesia
J. M. Cholwill, W. Wright, G. J. Hobbs and J. Curran
We have compared ondansetron 4 mg i.v. and cyclizine 50 mg i.v., in a
double-blind, randomized, placebo-controlled study for the prevention of
postoperative nausea and vomiting (PONV) for 24 h after day-case
gynaecological laparoscopy. Compared with placebo (n = 58), ondansetron (n
= 60) and cyclizine (n = 57) reduced significantly the incidence of
moderate or severe nausea (30% and 23% vs 52%; P = 0.02 and P = 0.001,
respectively) and requirement for escape antiemetic (28% and 16% vs 47%; P
= 0.04 and P < 0.001, respectively) before discharge from hospital.
There were no significant differences in PONV after discharge.
Significantly more patients suffered no PONV before and after discharge
after ondansetron and cyclizine compared with placebo (31% and 33% vs 12%;
P = 0.02 and P < 0.01, respectively). For diagnostic laparoscopy (n =
74), fewer patients received escape antiemetic after cyclizine than after
ondansetron (4% vs 37%; P < 0.01); for laparoscopic sterilization (n =
101), both antiemetics were equally effective. Ondansetron and cyclizine
both reduced severe and moderate nausea and the need for antiemetic therapy
after day-case gynaecological laparoscopy.
CLINICAL INVESTIGATIONS
Comparison of ondansetron and cyclizine for prevention of nausea and vomiting after day-case gynaecological laparoscopy
Department of Anaesthesia, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK; University Department of Anaesthesia, Queen's Medical Centre, Nottingham NG7 2UH, UK
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