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British Journal of Anaesthesia, Vol 83, Issue 2 333-335, Copyright © 1999 by The Board of Management and Trustees of the British Journal of Anaesthesia

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Effects of i.v. anaesthetic agents on the chemotaxis of eosinophils in vitro

W. Krumholz, O. Abdulle, J. Knecht and G. Hempelmann
Abteilung Anaesthesie und Operative Intensivmedizin, Bethlehem-Krankenhaus, Steinfeldstrasse 5, D-52222 Stolberg, Germany; Abteilung Anaesthesiologie und Operative Intensivmedizin, Justus-Liebig-Universitat, Rudolf-Buchheim- Strasse 7, D-35385 Giessen, Germany

Polymorphonuclear eosinophilic leucocytes (PME) participate in wound healing processes, the inflammatory response, bronchial asthma, allergies and defence against invading parasites. We have examined the effects of thiopental, methohexital, propofol, etomidate and ketamine on PME chemotaxis in vitro. PME were isolated from venous blood samples of 10 healthy volunteers using multi-stage Percoll gradient centrifugation. Eosinophilic chemotaxis was determined using a 48-well microchemotaxis chamber. Thiopental 150 micrograms ml-1 and etomidate 0.32 microgram ml-1 caused significant (P < or = 0.05) inhibition of PME chemotaxis. We conclude that thiopental and etomidate may have an adverse influence on wound healing processes and parasitic diseases. Further studies are recommended.
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