British Journal of Anaesthesia, Vol 83, Issue 2 330-332, Copyright © 1999 by The Board of Management and Trustees of the British Journal of Anaesthesia
T. G. Ruttmann and MFM. James
We have conducted an in vitro coagulation study, using the
thrombelastograph (TEG), to determine if the enhanced coagulability of
whole blood after haemodilution with normal saline can still be
demonstrated after administration of an antiplatelet agent. Aspirin
inhibits the platelet-endothelial interaction that is part of the
coagulation process. We investigated the role of aspirin in the phenomenon
of haemodilution-induced coagulability to identify if the
platelet-endothelial system is involved in the process. Previous work
showed that the TEG is not altered by oral ingestion of aspirin. Blood from
20 volunteers was divided into two aliquots of 4 ml each. One sample was
diluted by 20% by addition of 0.9% saline 1 ml while the other was not
diluted and served as a control. Coagulation studies were performed using
the TEG and enhanced coagulation was seen in the saline diluted samples.
Subjects then received soluble aspirin 375 mg daily for 3 days, after which
the tests were repeated. There was no difference in the control TEG values
and saline enhancement of coagulation was preserved in all subjects after 3
days of aspirin administration. We conclude that aspirin had no effect on
the observation that haemodilution with saline enhances the coagulability
of whole blood.
SHORT COMMUNICATIONS
Pro-coagulant effect of in vitro haemodilution is not inhibited by aspirin
Department of Anaesthesia, University of Cape Town Medical School, Observatory, Cape 7925, South Africa
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