Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (30)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Cobby, T. F.
Right arrow Articles by Hobbs, G. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cobby, T. F.
Right arrow Articles by Hobbs, G. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, Vol 83, Issue 2 253-256, Copyright © 1999 by The Board of Management and Trustees of the British Journal of Anaesthesia

CLINICAL INVESTIGATIONS

Rectal paracetamol has a significant morphine-sparing effect after hysterectomy

T. F. Cobby, I. M. Crighton, K. Kyriakides and G. J. Hobbs
University Department of Anaesthetics, Queen's Medical Centre, Nottingham NG7 2UH, UK

We have evaluated the morphine-sparing effect of rectal paracetamol during the first 24 h after abdominal hysterectomy in a placebo- controlled, double-blind study. We studied 72 patients receiving patient-controlled analgesia (PCA) with i.v. morphine after a standardized anaesthetic, allocated randomly to receive rectal paracetamol 1.3 g, diclofenac 50 mg or placebo, after wound closure and at 8 and 16 h. Suppositories were blinded by the hospital pharmacy. Study violations excluded data from seven patients. Patient data, morphine doses during anaesthesia and recovery, and sedation and nausea scores were comparable. Mean morphine consumption during PCA was 35.0 (SD 20.4) mg, 32.7 (27.4) mg and 54.9 (28.3) mg in the paracetamol (n = 24), diclofenac (n = 20) and placebo (n = 21) groups, respectively (P < 0.05). Morphine sparing during PCA for paracetamol and diclofenac (36% vs 40% over 24 h) was significant from 4 h. Global scores of average pain over 24 h were lower after diclofenac compared with paracetamol (P < 0.01) and placebo (P = 0.08). We conclude that rectal paracetamol was an efficacious adjuvant analgesic after regular dosing.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Br J AnaesthHome page
C. Remy, E. Marret, and F. Bonnet
Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials
Br. J. Anaesth., April 1, 2005; 94(4): 505 - 513.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
M. Stockler, J. Vardy, A. Pillai, and D. Warr
Acetaminophen (Paracetamol) Improves Pain and Well-Being in People With Advanced Cancer Already Receiving a Strong Opioid Regimen: A Randomized, Double-Blind, Placebo-Controlled Cross-Over Trial
J. Clin. Oncol., August 15, 2004; 22(16): 3389 - 3394.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
P. Sigston, D. Yates, S. Leonardi, A. Ng, and G. Smith
Use of PCA morphine as the sole analgesic for postoperative pain relief after TAH
Br. J. Anaesth., December 1, 2003; 91(6): 923 - 923.
[Full Text] [PDF]

Home page
 Br J AnaesthHome page
H. Viitanen, N. Tuominen, H. Vaaraniemi, E. Nikanne, and P. Annila
Analgesic efficacy of rectal acetaminophen and ibuprofen alone or in combination for paediatric day-case adenoidectomy{dagger}
Br. J. Anaesth., September 1, 2003; 91(3): 363 - 367.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Pharmacy PracticeHome page
P. J. S. Koo
Acute Pain Management
Journal of Pharmacy Practice, August 1, 2003; 16(4): 231 - 248.
[Abstract] [PDF]

Home page
 Anesth. Analg.Home page
M. F. Watcha, T. Issioui, K. W. Klein, and P. F. White
Costs and Effectiveness of Rofecoxib, Celecoxib, and Acetaminophen for Preventing Pain After Ambulatory Otolaryngologic Surgery
Anesth. Analg., April 1, 2003; 96(4): 987 - 994.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
F. Aubrun, F. Kalfon, P. Mottet, A. Bellanger, O. Langeron, P. Coriat, and B. Riou
Adjunctive analgesia with intravenous propacetamol does not reduce morphine-related adverse effects
Br. J. Anaesth., March 1, 2003; 90(3): 314 - 319.
[Abstract] [Full Text] [PDF]

Home page
 QJMHome page
C.L. SHEEN, J.F. DILLON, D.N. BATEMAN, K.J. SIMPSON, and T.M. MACDONALD
Paracetamol toxicity: epidemiology, prevention and costs to the health-care system
QJM, September 1, 2002; 95(9): 609 - 619.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
A. Ng, J. Parker, L. Toogood, B. R. Cotton, and G. Smith
Does the opioid-sparing effect of rectal diclofenac following total abdominal hysterectomy benefit the patient?
Br. J. Anaesth., May 1, 2002; 88(5): 714 - 716.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
T. Issioui, K. W. Klein, P. F. White, M. F. Watcha, M. Coloma, G. D. Skrivanek, S. B. Jones, K. C. Thornton, and B. F. Marple
The Efficacy of Premedication with Celecoxib and Acetaminophen in Preventing Pain After Otolaryngologic Surgery
Anesth. Analg., May 1, 2002; 94(5): 1188 - 1193.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
M. Hyllested, S. Jones, J. L. Pedersen, and H. Kehlet
Comparative effect of paracetamol, NSAIDs or their combination in postoperative pain management: a qualitative review
Br. J. Anaesth., February 1, 2002; 88(2): 199 - 214.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
J. Romsing, S. Moiniche, and J. B. Dahl
Rectal and parenteral paracetamol, and paracetamol in combination with NSAIDs, for postoperative analgesia
Br. J. Anaesth., February 1, 2002; 88(2): 215 - 226.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
H. Jorgensen, J. S. Fomsgaard, J. Dirks, J. Wetterslev, B. Andreasson, and J. B. Dahl
Effect of peri- and postoperative epidural anaesthesia on pain and gastrointestinal function after abdominal hysterectomy
Br. J. Anaesth., October 1, 2001; 87(4): 577 - 583.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.