British Journal of Anaesthesia, Vol 82, Issue 6 890-899, Copyright © 1999 by The Board of Management and Trustees of the British Journal of Anaesthesia
R. N. Upton and G. L. Ludbrook
We describe a six-compartment kinetic and dynamic physiological model of
induction of anaesthesia with thiopental. The model included an accurate
account of initial drug distribution by representing the inter-
relationships between initial vascular mixing, lung kinetics and cardiac
output, and the use of the brain as the target organ for anaesthesia
(two-compartment sub-model with slight membrane limitation). It also
accounted for thiopental-induced reductions in cerebral blood flow and
cardiac output. Parameters for the model were estimated using hybrid
modelling from an extensive in vivo data set collected in sheep.
Simulations were used to compare the properties of the thiopental model
with an analogous previously published model of propofol. Differences in
the blood:brain equilibrium half-lives of thiopental (1.22 min) and
propofol (4.32 min) contributed to significant differences in the predicted
optimal rate of bolus injection of each agent for inducing anaesthesia in
sheep.
LABORATORY INVESTIGATIONS
A model of the kinetics and dynamics of induction of anaesthesia in sheep: variable estimation for thiopental and comparison with propofol
Department of Anaesthesia and Intensive Care, Royal Adelaide Hospital, University of Adelaide, North Terrace, Adelaide, SA 5005, Australia
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  R. N. Upton, A. M. Martinez, and C. Grant Comparison of the sedative properties of CNS 7056, midazolam, and propofol in sheep Br. J. Anaesth., December 1, 2009; 103(6): 848 - 857. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Weiss, T. C. Krejcie, and M. J. Avram A Minimal Physiological Model of Thiopental Distribution Kinetics Based on a Multiple Indicator Approach Drug Metab. Dispos., September 1, 2007; 35(9): 1525 - 1532. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Voss, G. Ludbrook, C. Grant, R. Upton, and J. W. Sleigh A Comparison of Pharmacokinetic/Pharmacodynamic versus Mass-Balance Measurement of Brain Concentrations of Intravenous Anesthetics in Sheep Anesth. Analg., June 1, 2007; 104(6): 1440 - 1446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rasmussen, R. N. Upton, C. Grant, A. M. Martinez, G. E. Cold, and G. Ludbrook The effects of indomethacin on intracranial pressure and cerebral hemodynamics during isoflurane or propofol anesthesia in sheep with intracranial hypertension. Anesth. Analg., June 1, 2006; 102(6): 1823 - 1829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. N. Upton, C. Grant, A. M. Martinez, and G. L. Ludbrook Recirculatory model of fentanyl disposition with the brain as the target organ Br. J. Anaesth., November 1, 2004; 93(5): 687 - 697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. N. Upton The two-compartment recirculatory pharmacokinetic model--an introduction to recirculatory pharmacokinetic concepts Br. J. Anaesth., April 1, 2004; 92(4): 475 - 484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Boer Drug handling by the lungs Br. J. Anaesth., July 1, 2003; 91(1): 50 - 60. [Full Text] [PDF]
|
|
|
|
|
|
D. Zheng, R. N. Upton, and A. M. Martinez The Contribution of the Coronary Concentrations of Propofol to Its Cardiovascular Effects in Anesthetized Sheep Anesth. Analg., June 1, 2003; 96(6): 1589 - 1597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. F. White and J. G. Bovill From SIVA to ISAP!--A Logical Evolution Anesth. Analg., January 1, 2001; 92(1): 1 - 2. [Full Text] [PDF]
|
|