British Journal of Anaesthesia, Vol 82, Issue 6 875-880, Copyright © 1999 by The Board of Management and Trustees of the British Journal of Anaesthesia
M. Naguib and A. H. Samarkandi
We have evaluated the perioperative effects of melatonin with those of
midazolam in 75 women in a prospective, randomized, double-blind,
placebo-controlled study. Patients were given sublingual midazolam 15 mg,
melatonin 5 mg or placebo, approximately 100 min before a standard
anaesthetic. Sedation, anxiety and orientation were quantified before, and
10, 30, 60 and 90 min after premedication, and 15, 30, 60 and 90 min after
admission to the recovery room. Psychomotor performance was evaluated at
these times also, using the digit-symbol substitution test (DSST) and the
Trieger dot test (TDT). Patients who received premedication with either
midazolam or melatonin had a significant decrease in anxiety levels and
increase in levels of sedation before operation compared with controls.
Midazolam produced the highest scores for sedation at 30 and 60 min after
administration and significant psychomotor impairment in the preoperative
period compared with melatonin or placebo. After operation, patients who
received midazolam or melatonin premedication had increased levels of
sedation at 30 min and impairment in performance on the DSST at 15, 30 and
90 min compared with controls. There were no significant differences
between the three groups for anxiety levels or TDT performance after
operation. Amnesia was notable only in the midazolam group for one
preoperative event (entry into the operating room). Patient satisfaction
was noted in the midazolam and melatonin groups only. We have demonstrated
that melatonin can be used effectively for premedication of adult patients.
CLINICAL INVESTIGATIONS
Premedication with melatonin: a double-blind, placebo-controlled comparison with midazolam
Department of Anaesthesiology, King Saud University, College of Medicine at King Khalid University Hospital, PO Box 7805, Riyadh 11472, Saudi Arabia
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  W. Caumo, F. Torres, N. L. Moreira Jr, J. A. S. Auzani, C. A. Monteiro, G. Londero, D. F. M. Ribeiro, and M. P. L. Hidalgo The Clinical Impact of Preoperative Melatonin on Postoperative Outcomes in Patients Undergoing Abdominal Hysterectomy Anesth. Analg., November 1, 2007; 105(5): 1263 - 1271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Naguib, A. H. Samarkandi, M. A. Moniem, E. E.-D. Mansour, A. A. Alshaer, H. A. Al-Ayyaf, A. Fadin, and S. W. Alharby The Effects of Melatonin Premedication on Propofol and Thiopental Induction Dose-Response Curves: A Prospective, Randomized, Double-Blind Study Anesth. Analg., December 1, 2006; 103(6): 1448 - 1452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Capuzzo, B. Zanardi, E. Schiffino, C. Buccoliero, D. Gragnaniello, S. Bianchi, and R. Alvisi Melatonin does not reduce anxiety more than placebo in the elderly undergoing surgery. Anesth. Analg., July 1, 2006; 103(1): 121 - 123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Mahmoud, N. Sarhill, and M. A. Mazurczak The therapeutic application of melatonin in supportive care and palliative medicine American Journal of Hospice and Palliative Medicine, July 1, 2005; 22(4): 295 - 309. [Abstract] [PDF]
|
|
|
|
|
|
M. Naguib, P. G. Schmid III, and M. T. Baker The Electroencephalographic Effects of IV Anesthetic Doses of Melatonin: Comparative Studies with Thiopental and Propofol Anesth. Analg., July 1, 2003; 97(1): 238 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Vijayalaxmi, C. R. Thomas Jr, R. J. Reiter, and T. S. Herman Melatonin: From Basic Research to Cancer Treatment Clinics J. Clin. Oncol., May 15, 2002; 20(10): 2575 - 2601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Guo, E. Kuzumi, S. C. Charman, and A. Vuylsteke Perioperative Melatonin Secretion in Patients Undergoing Coronary Artery Bypass Grafting Anesth. Analg., May 1, 2002; 94(5): 1085 - 1091. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Naguib and A. H. Samarkandi The Comparative Dose-Response Effects of Melatonin and Midazolam for Premedication of Adult Patients: A Double-Blinded, Placebo-Controlled Study Anesth. Analg., August 1, 2000; 91(2): 473 - 479. [Abstract] [Full Text] [PDF]
|
|