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British Journal of Anaesthesia, Vol 82, Issue 5 767-769, Copyright © 1999 by The Board of Management and Trustees of the British Journal of Anaesthesia

SHORT COMMUNICATIONS

Differential effects of isoflurane and i.v. anaesthetic agents on metabolism of alveolar type II cells

S. Molliex, B. Crestani, B. Dureuil, C. Rolland, M. Aubier and J. M. Desmonts
Department d'Anesthesie, Pr Auboyer, Hopital Bellevue, Bd Pasteur, F-42055, St-Etienne Cedex 2, France; Unite INSERM 408, Faculte de Medecine Bichat, 16 rue Henri Huchard, F-75018 Paris, France; Department d'Anesthesie, Pr Desmonts, Hopital Bichat, 46 rue Henri Huchard, F-75877 Paris, France

Alveolar type II (ATII) cells perform many important functions within the lung, including surfactant metabolism. We have investigated the effects of isoflurane and different i.v. anaesthetics on cell metabolism in primary cultures of rat ATII cells. Biosynthesis of phosphatidylcholine, the main phospholipid component of surfactant, was decreased in cells exposed to isoflurane in a dose- and time-related manner. This effect was fully reversible within 2 h after isoflurane removal. Lactate dehydrogenase (LDH) release, an index of cell damage, was increased with isoflurane exposure (1%) over a long incubation period (8-12 h). Enhanced lactate production, reflecting an increase in glycolytic metabolism, was also observed in isoflurane exposed cells. In contrast, metabolism of ATII cells was moderately affected by i.v. anaesthetics. Our data suggest differential metabolism of alveolar homeostasis depending on the anaesthetic agent used.
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