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British Journal of Anaesthesia, Vol 82, Issue 5 718-722, Copyright © 1999 by The Board of Management and Trustees of the British Journal of Anaesthesia

CLINICAL INVESTIGATIONS

Effect of riluzole on acute pain and hyperalgesia in humans

N. A. Hammer, J. Lilleso, J. L. Pedersen and H. Kehlet
Department of Surgical Gastroenterology, Hvidovre University Hospital, Kettegaard Alle 30, DK-2650 Hvidovre, Denmark

Riluzole modulates several transmitter systems which may be involved in nociception. Antinociceptive effects have been shown in animal studies, but there are no human data. Therefore, we have examined the acute analgesic effect of riluzole in a human model of inflammatory pain induced by a thermal injury on the distal leg (47 degrees C, 7 min, 12.5 cm2) in 20 healthy volunteers. Hyperalgesia to mechanical and heat stimuli were examined by von Frey hairs and thermodes. We used a randomized, double-blind, placebo-controlled design, and subjects received riluzole 100 mg or placebo for 2 days with a 14-day interval. The burns produced significant hyperalgesia, but riluzole had no acute analgesic effects in normal or hyperalgesic skin.
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