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British Journal of Anaesthesia, Vol 82, Issue 3 355-359, Copyright © 1999 by The Board of Management and Trustees of the British Journal of Anaesthesia

CLINICAL INVESTIGATIONS

Recovery after anaesthesia for pulmonary surgery: desflurane, sevoflurane and isoflurane

J. Dupont, B. Tavernier, Y. Ghosez, L. Durinck, A. Thevenot, N. Moktadir-Chalons, L. Ruyffelaere-Moises, N. Declerck and P. Scherpereel
Department d'Anesthesie Reanimation Chirurgicale II, CHRU, Lille, France; C.H.R. Hopital de Warquignies Boussu, Belgique

We have studied maintenance and recovery profiles after general anaesthesia with sevoflurane, desflurane and isoflurane in 100 patients undergoing pulmonary surgery. End-tidal concentrations of anaesthetic required to maintain mean arterial pressure and heart rate within 20% of baseline values were 1.4 +/- 0.6% for sevoflurane, 3.4 +/- 0.9% for desflurane and 0.7 +/- 0.3% for isoflurane. The three anaesthetics had comparable haemodynamic effects and arterial oxygenation during one- lung ventilation. Emergence was twice as fast with desflurane than with sevoflurane or isoflurane (mean times to extubation: 8.9 (SD 5.0) min, 18.0 (17.0) min and 16.2 (11.0) min for desflurane, sevoflurane and isoflurane, respectively). Early recovery (Aldrete score, cognitive and psychomotor functions) was also more rapid after desflurane. In pulmonary surgery, desflurane, but not sevoflurane, allowed more rapid emergence and earlier recovery than isoflurane.
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