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British Journal of Anaesthesia, Vol 82, Issue 2 274-276, Copyright © 1999 by The Board of Management and Trustees of the British Journal of Anaesthesia

SHORT COMMUNICATIONS

Antiemetic activity of the NK1 receptor antagonist GR205171 in the treatment of established postoperative nausea and vomiting after major gynaecological surgery

P. Diemunsch, P. Schoeffler, B. Bryssine, L. E. Cheli-Muller, J. Lees, B. A. McQuade and C. F. Spraggs
Hospital Civil, Strasbourg, France; Hotel-Dieu, Clermont-Ferrand, France; Hotel-Dieu, Lyon, France; Laboratoire Glaxo Wellcome SAS, Paris, France; Department of Clinical Statistics and Department of Oncology and Emesis Clinical Research, Glaxo Wellcome Research and Development, Greenford, Middlesex UB6 OHE, UK

In this double-blind, randomized, parallel group study, we have investigated the antiemetic activity of the potent and selective NK1 receptor antagonist GR205171 25 mg i.v. compared with placebo in the treatment of established postoperative nausea and vomiting (PONV) in patients after major gynaecological surgery performed under general anaesthesia. The incidence of PONV in the study population was 65%. Thirty-six patients were treated with placebo or GR205171 (18 patients per group). GR205171 produced greater control of PONV than placebo over the 24-h assessment period. The stimuli for emesis after PONV are multifactorial and the efficacy of GR205171 in this study supports the broad spectrum potential for NK1 receptor antagonists in the management of postoperative emesis. GR205171 was well tolerated and no adverse events were reported that would preclude the further development of this agent.
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