British Journal of Anaesthesia, Vol 82, Issue 2 244-249, Copyright © 1999 by The Board of Management and Trustees of the British Journal of Anaesthesia
S. Jinks, J. F. Antognini, E. Carstens, V. Buzin and C. Simons
We have examined the response of lumbar dorsal horn cells to a noxious
mechanical stimulus during differential delivery of isoflurane to the brain
and spinal cord of goats. We hypothesized that isoflurane, acting in the
brain, would depress dorsal horn neuronal responses to a noxious mechanical
stimulus applied to the hindlimb. Eight goats were anaesthetized with
isoflurane and neck dissections performed which allowed cranial bypass.
Lumbar laminectomies were performed to allow measurements of single-unit
dorsal horn neuronal activity. Isoflurane 1.3% was administered before
bypass, and during differential delivery it was administered at each of the
following head/torso combinations: 1.3%/1.3%, 0.8%/1.3%, 0.3%/1.3%,
1.3%/0.8%, 0.8%/0.8% and 0.3%/0.8%. When the torso isoflurane concentration
was 1.3%, decreasing cranial isoflurane from 1.3% to 0.3% did not
significantly affect dorsal horn responses (from mean 325 (SD 262) to 379
(412) impulses min-1; P < 0.05). However, when torso isoflurane was
0.8%, decreasing cranial isoflurane from 1.3% to 0.3% increased mean evoked
dorsal horn activity by 42% (388 (359) to 551 (452) impulses min-1; P <
0.05). These data suggest that the major effect of isoflurane on dorsal
horn responses to noxious stimuli is direct, but there is an indirect
effect occurring via descending projections from supraspinal regions.
LABORATORY INVESTIGATIONS
Isoflurane can indirectly depress lumbar dorsal horn activity in the goat via action within the brain
Section of Neurobiology, Physiology and Behavior and Department of Anesthesiology, University of California, Davis, CA 95616, USA
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