British Journal of Anaesthesia, Vol 82, Issue 2 221-227, Copyright © 1999 by The Board of Management and Trustees of the British Journal of Anaesthesia
K. Perttunen, E. Nilsson and E. Kalso
We studied intensity of pain, cumulative morphine consumption, ventilatory
and renal function, and haemostasis in patients undergoing video-assisted
thoracoscopic surgery and receiving a 2-day i.v. infusion of diclofenac,
ketorolac or saline. Plasma concentrations of the two NSAID were also
measured. The study was randomized, double- blind and placebo-controlled,
with 10 patients in each group. Patients experienced mainly moderate pain.
Mean consumption of i.v. morphine during the first day after operation was
57 (SEM 11) mg in the placebo group. Diclofenac and ketorolac were equally
effective in reducing total morphine consumption (61% and 52%,
respectively). Adverse events were similar and minor. Greater variability
in plasma concentrations of ketorolac were detected compared with
diclofenac.
CLINICAL INVESTIGATIONS
I.v. diclofenac and ketorolac for pain after thoracoscopic surgery
Department of Anaesthesia, Helsinki University Central Hospital and Department of Clinical Pharmacology, University of Helsinki, Haartmaninkatu 4, FIN-00290 Helsinki, Finland
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