British Journal of Anaesthesia, Vol 82, Issue 1 112-116, Copyright © 1999 by The Board of Management and Trustees of the British Journal of Anaesthesia
S. T. Ho, J. J. Wang, W. J. Liaw, H. K. Lee and S. C. Lee
Nociceptive stimuli, such as formalin-induced pain and adjuvant-induced
arthritis, attenuate tolerance to morphine antinociception. In this study,
we have explored the effect of upper and lower abdominal surgical pain on
the prevention of acute tolerance to morphine antinociception in
Sprague-Dawley rats. Group I received lower abdominal surgery (LAS) and
i.v. morphine infusion; group II received LAS and i.v. saline infusion;
group III received upper abdominal surgery (UAS) and i.v. morphine
infusion; group IV received UAS and i.v. saline infusion; group V received
i.v. morphine infusion; and group VI received i.v. saline infusion. The
antinociceptive effects of morphine were measured by an infrared thermal
tail flick test. We also measured plasma concentrations of morphine in rats
receiving morphine infusions with or without surgical treatment. We found
that acute tolerance to morphine antinociception developed after 2 h
following i.v. infusion of morphine alone. However, both UAS and LAS
significantly slowed the rate of development of acute tolerance to
morphine. The area under the time-response curves (AUC) of groups I and III
were mean 34,556 (SD 5607) and 32,548 (9783), respectively, which were
significantly different from that of group V (18,759 (8225)) (P < 0.01).
Also, there were no significant differences between groups I and III. There
were no significant differences between groups for plasma morphine
concentrations during the 8-h study (e.g. groups I, III and V: 179.9
(22.6), 182.7 (14.4) and 170.9 (15.8) ng ml-1 at 8 h, respectively) and we
suggest that the appearance of acute morphine tolerance after morphine
infusion is not pharmacokinetic in nature.
LABORATORY INVESTIGATIONS
Surgical pain attenuates acute morphine tolerance in rats
Department of Anaesthesiology, National Defence Medical Centre/Tri- Service General Hospital, Taipei, Taiwan; Department of Anaesthesiology, National Defence Medical Centre/Tri-Service General Hospital and Cathay General Hospital, Taipei, Taiwan; Department of Anaesthesiology, Tri-Service General Hospital and Graduate Institute of Medical Sciences, National Defence Medical Centre, Taipei, Taiwan; Department of Pharmacology, National Defence Medical Centre National Defence Medical Centre/Tri-Service General Hospital, Taipei, Taiwan; and Department of Surgery, National Defence Medical Centre/Tri-Service General Hospital, Taipei, Taiwan
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