British Journal of Anaesthesia, Vol 81, Issue 6 972-973, Copyright © 1998 by The Board of Management and Trustees of the British Journal of Anaesthesia
R. Fisher, O. Hung, M. Mezei and R. Stewart
In this randomized, double-blind study, we have compared the ability of 5%
liposome-encapsulated tetracaine (amethocaine) (LET) vs 5% eutectic mixture
of local anaesthetics (EMLA) to produce local anaesthesia of intact skin in
40 healthy volunteers. Volunteers had both preparations applied to their
forearms under an occlusive dressing for 1 h. Superficial anaesthesia was
measured by a total of nine 1-mm pinpricks on each arm. Deeper anaesthesia
was assessed by single insertion of a sterile 22-gauge needle to a depth of
3 mm and pain was reported on a visual analogue scale (VAS). If the
volunteer perceived greater than four of the 1-mm pinpricks, the 3-mm
insertion was not performed. Results showed that the number of pinpricks
perceived was significantly less (P < 0.01) for LET (median 1.0; range
0-9) vs EMLA (1.5; 0-9). In volunteers who had deeper anaesthesia assessed,
there was no significant difference (P = 0.065) in VAS scores for LET (mean
1.5 (SD 1.4); n = 34) vs EMLA (2.4 (2.1); n = 28). Overall anaesthetic
effect, as ranked by all of the subjects, was significantly better for LET
compared with EMLA (P = 0.024). We have demonstrated that when applied in
equal volumes, 5% LET produced better superficial local anaesthesia than
EMLA.
SHORT COMMUNICATIONS
Topical anaesthesia of intact skin: liposome-encapsulated tetracaine vs EMLA
Discipline of Family Practice, Memorial University of Newfoundland, St John's, Newfoundland, Canada; Department of Anaesthesia, Dalhousie University, Halifax, Nova Scotia, Canada; College of Pharmacy, Dalhousie University, Halifax, Nova Scotia, Canada
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