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British Journal of Anaesthesia, Vol 81, Issue 6 940-944, Copyright © 1998 by The Board of Management and Trustees of the British Journal of Anaesthesia

LABORATORY INVESTIGATIONS

High predictive value of red cell volume measurement using carboxy- haemoglobin in a rabbit model of haemorrhage

H. Obata, F. Goto, T. Nara, F. Kunimoto, N. Oriuchi, E. Mishiba and M. Nemoto
Department of Anaesthesiology and Reanimatology, Gunma University School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan; Department of Nuclear Medicine, Gunma University School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan; Kitasato University School of Medicine, Kitsato, Japan

We have studied the accuracy of blood volume measurements using carbon monoxide (CO)-labelled haemoglobin (COHb) injection and dilution (CO method) by comparing changes in red cell volume (RCV) measured using the CO method and 51Cr-labelled erythrocyte dilution (51Cr method) in a haemorrhage and infusion model in rabbits. RCV was measured repeatedly using the CO method at four different blood volume stages (stages I- IV). At stages I and IV, RCV was measured simultaneously using the 51Cr method. In comparing the sum of the circulating RCV and extracted RCV (SUM RCV) using the CO method, the values were almost equal and there were no significant differences between the values at the four stages. In comparing circulating RCV measured using the CO method and the 51Cr method, mean difference between the two methods was 0.80 (SD 0.76) ml kg-1 or 4.7 (4.6)%, and a positive correlation was observed (r = 0.91). We conclude that the CO method can be used to measure blood volume during perioperative periods in infants because it avoids use of a radioactive tracer, is simple and repeated measurements are possible.
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M. Sawano, T. Mato, and H. Tsutsumi
Bedside red cell volumetry by low-dose carboxyhaemoglobin dilution using expiratory gas analysis
Br. J. Anaesth., February 1, 2006; 96(2): 186 - 194.
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