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British Journal of Anaesthesia, Vol 81, Issue 5 782-784, Copyright © 1998 by The Board of Management and Trustees of the British Journal of Anaesthesia

SHORT COMMUNICATIONS

A single dose of milrinone facilitates separation from cardiopulmonary bypass in patients with pre-existing left ventricular dysfunction

E. B. Lobato, O. Florete Jr and H. L. Bingham
Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL, USA; Department of Anesthesiology, University Medical Center, Jacksonville, FL, USA

Milrinone is used during cardiac surgery to facilitate separation from cardiopulmonary bypass (CPB) and/or to treat myocardial dysfunction in the post-bypass period. We have demonstrated, in patients with preoperative depression of systolic function undergoing aorto-coronary artery bypass surgery, sustained improvement in cardiac function after a single loading dose of milrinone 50 micrograms kg-1, administered at the end of bypass, thus significantly decreasing the need for beta- agonist therapy.
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