British Journal of Anaesthesia, Vol 81, Issue 5 766-770, Copyright © 1998 by The Board of Management and Trustees of the British Journal of Anaesthesia
H. Kinoshita, K. Ishida and T. Ishikawa
ATP-sensitive potassium channel openers are used as vasodilators in the
treatment of cardiovascular disorders. The effects of i.v. anaesthetics on
arterial relaxation induced by ATP-sensitive potassium channel openers have
not been studied. Therefore, in this study, we have examined if thiopental
(thiopentone) and propofol affect the vascular response to the
ATP-sensitive potassium channel openers, cromakalim and pinacidil, in the
isolated rat aorta. Rings of rat thoracic aortas without endothelium were
suspended for isometric force recording. Concentration-response curves were
obtained in a cumulative manner. During submaximal contractions with
phenylephrine 0.3 microgramsmol litre-1, relaxation after cromakalim 0.1-30
microgramsmol litre-1, pinacidil 0.1-30 microgramsmol litre-1 and
papaverine 0.1-300 microgramsmol litre-1 was demonstrated. Thiopental
30-300 microgramsmol litre-1, propofol 10-100 microgramsmol litre-1, 10%
Intralipid 45 microliters or glibenclamide 5 microgramsmol litre-1 were
applied 15 min before addition of phenylephrine. During contractions with
phenylephrine, cromakalim and pinacidil induced concentration-dependent
relaxation. A selective ATP-sensitive potassium channel antagonist,
glibenclamide 5 microgramsmol litre-1, abolished this relaxation, whereas
it did not affect relaxation produced by papaverine. Thiopental
concentrations > 30 microgramsmol litre-1 significantly impaired
relaxation produced by cromakalim or pinacidil. Propofol concentrations
> 10 microgramsmol litre-1 also significantly reduced relaxation
produced by cromakalim or pinacidil, whereas Intralipid was ineffective.
Thiopental 300 microgramsmol litre-1 and propofol 100 microgramsmol litre-1
did not alter relaxation produced by papaverine. These results suggest that
the i.v. anaesthetics, thiopental and propofol, impaired vasodilatation
mediated by ATP-sensitive potassium channels in vascular smooth muscle
cells.
LABORATORY INVESTIGATIONS
Thiopental and propofol impair relaxation produced by ATP-sensitive potassium channel openers in the rat aorta
Department of Anaesthesiology-Resuscitology, Yamaguchi University School of Medicine, 1144 Kogushi, Ube Yamaguchi 755-8505, Japan
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