British Journal of Anaesthesia, Vol 81, Issue 5 742-747, Copyright © 1998 by The Board of Management and Trustees of the British Journal of Anaesthesia
S. Petersen-Felix, M. Luginbuhl, T. W. Schnider, M. Curatolo, L. Arendt-Nielsen and A. M. Zbinden
We have compared the analgesic potency of MAC-equivalent concentrations of
xenon (10, 20, 30 and 40%) and nitrous oxide (15, 30, 45 and 60%) in humans
using a multimodal experimental pain testing and assessment technique. We
tested 12 healthy volunteers in a randomized, single- blind, crossover
study. The following experimental pain tests were used: nociceptive reflex
to repeated stimuli; pain tolerance to maximal effort tourniquet ischaemia;
electrical stimulation; mechanical pressure; and cold. Reaction time was
also measured. Xenon and nitrous oxide produced analgesia to ischaemic,
electrical and mechanical stimulation, but not to cold pain. There was no
difference in MAC- equivalent concentrations of xenon and nitrous oxide.
Both increased reaction time in a similar manner. Xenon and nitrous oxide
evoked nausea and vomiting in a large number of volunteers.
CLINICAL INVESTIGATIONS
Comparison of the analgesic potency of xenon and nitrous oxide in humans evaluated by experimental pain
Department of Anaesthesiology and Intensive Care, University Hospital of Bern, Bern, Switzerland; Centre for Sensory-Motor Interaction, Laboratory for Experimental Pain Research, University of Aalborg, Denmark
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