British Journal of Anaesthesia, Vol 81, Issue 5 737-741, Copyright © 1998 by The Board of Management and Trustees of the British Journal of Anaesthesia
J. F. Coetzee and H. van Loggerenberg
Tramadol may cause awareness and EEG activation during anaesthesia. We
compared tramadol with morphine, administered during wound-closure,
surmising that tramadol may cause earlier awakening, more rapid recovery,
less respiratory depression and equivalent pain relief. Forty patients
received nitrous oxide-enflurane for abdominal surgery. At wound closure,
patients received tramadol 3 mg kg-1 or morphine 0.2 mg kg-1 and end-tidal
enflurane concentrations were maintained at 0.5 kPa until skin closure,
whereupon anaesthesia was discontinued. Times to spontaneous respiration,
awakening and orientation were similar in the two groups, as were blood-gas
tensions, ventilatory frequency, pain scores and incidence of nausea. Half
of each group required supplementary analgesia during their 90-min stay in
the recovery room. P-deletion counts improved more rapidly in the tramadol
group. This study confirms previous reports that tramadol did not
antagonize the hypnotic effects of volatile anaesthetics. Tramadol,
administered during operation, was as effective as morphine in providing
postoperative analgesia while permitting more rapid psychomotor recovery.
CLINICAL INVESTIGATIONS
Tramadol or morphine administered during operation: a study of immediate postoperative effects after abdominal hysterectomy
Department of Anaesthesiology, Faculty of Medicine, University of Stellenbosch, PO Box 19063, Tygerberg, 7505, South Africa; Department of Anaesthesiology, Tygerberg Hospital, Private Bag, Tygerberg 7575, South Africa
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