British Journal of Anaesthesia, Vol 81, Issue 4 526-528, Copyright © 1998 by The Board of Management and Trustees of the British Journal of Anaesthesia
Y. Fujii, Y. Saitoh, H. Tanaka and H. Toyooka
We have evaluated the efficacy and safety of granisetron, a selective 5-
hydroxytryptamine type-3 receptor antagonist, for the prevention of
postoperative nausea and vomiting (PONV) in women undergoing thyroidectomy.
In a prospective, randomized, placebo-controlled, double- blind study, 100
ASA I patients, aged 30-57 yr, received placebo or granisetron at three
different doses (20, 40 or 100 micrograms kg-1) (n = 25 each), i.v.,
immediately before induction of anaesthesia. A standard general anaesthetic
technique was used. A complete response, defined as no PONV and no need for
another rescue antiemetic during the first 3 h after anaesthesia, was seen
in 36%, 44%, 92% and 92% of patients who received placebo, granisetron 20
micrograms kg-1, 40 micrograms kg-1 and 100 micrograms kg-1, respectively;
corresponding values during the next 21 h after anaesthesia were 40%, 44%,
88%, and 88% (P < 0.05; overall Fisher's exact probability test). There
were no clinically important adverse events in any group. We conclude that
granisetron 40 micrograms kg-1 was an effective antiemetic for the
prevention of PONV after thyroidectomy. Increasing the dose to 100
micrograms kg-1 provided no further benefit.
CLINICAL INVESTIGATIONS
Prophylactic antiemetic therapy with granisetron in women undergoing thyroidectomy
Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, 2-1-1, Amakubo, Tsukuba City Ibaraki 305, Japan; Department of Anaesthesiology and Critical Care Medicine, Tokyo Medical and Dental University School of Medicine, Bunkyo-ku, Tokyo, Japan; Department of Anaesthesiology, Toride Kyodo General Hospital, Toride City, Ibaraki, Japan
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