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British Journal of Anaesthesia, Vol 81, Issue 3 390-392, Copyright © 1998 by The Board of Management and Trustees of the British Journal of Anaesthesia

CLINICAL INVESTIGATIONS

Oral granisetron prevents postoperative vomiting in children

Y. Fujii, H. Toyooka and H. Tanaka
Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, 2-1-1, Amakubo, Tsukuba City, Ibaraki 305, Japan; Department of Anaesthesiology, Toride Kyodo General Hospital, Toride City, Ibaraki, Japan

We have studied the efficacy of granisetron, a selective 5- hydroxytryptamine type 3 receptor antagonist, administered orally for the prevention of postoperative vomiting after tonsillectomy in children. In a randomized, double-blind, placebo-controlled study, 160 paediatric patients, ASA 1, aged 4-10 yr, received placebo or granisetron (20, 40 or 80 micrograms kg-1) (n = 40 each) orally, 1 h before surgery. A standard general anaesthetic technique was used throughout. A complete response, defined as no emesis and no need for another rescue antiemetic during the first 24 h after anaesthesia, occurred in 40%, 48%, 85% and 90% of patients who had received placebo, or granisetron 20, 40 or 80 micrograms kg-1, respectively (P < 0.05; overall Fisher's exact probability test). There were no clinically important adverse events. We conclude that preoperative oral granisetron, in doses more than 40 micrograms kg-1, was effective for the prevention of postoperative vomiting in children.
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C. M. Bolton, P. S. Myles, T. Nolan, and J. A. Sterne
Prophylaxis of postoperative vomiting in children undergoing tonsillectomy: a systematic review and meta-analysis
Br. J. Anaesth., November 1, 2006; 97(5): 593 - 604.
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