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British Journal of Anaesthesia, Vol 81, Issue 3 373-376, Copyright © 1998 by The Board of Management and Trustees of the British Journal of Anaesthesia

CLINICAL INVESTIGATIONS

Influence of timing of morphine administration on postoperative pain and analgesic consumption

A. Y. Millar, M. D. Mansfield and J. Kinsella
Directorate of Anaesthesia, Walton Building, Glasgow Royal Infirmary University NHS Trust, 84 Castle Street, Glasgow G4 OSF and University Department of Anaesthesia, 8-16 Alexandra Parade, Glasgow G31 2ER

We have investigated if a pre-emptive dose of morphine, given 30 min before skin incision, influenced postoperative pain and morphine consumption after hysterectomy. In a prospective, randomized, double- blind, placebo-controlled clinical study, patients received morphine 0.3 mg kg-1 at induction of anaesthesia or 30 min later at skin incision. The primary endpoint was defined as 24-h morphine consumption via patient-controlled analgesia. We could not demonstrate any difference between the two groups in morphine consumption or pain scores, and we conclude that there was no evidence of pre-emptive analgesia in this study.
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