British Journal of Anaesthesia, Vol 81, Issue 3 365-368, Copyright © 1998 by The Board of Management and Trustees of the British Journal of Anaesthesia
S. Schraag, G. N. Kenny, U. Mohl and M. Georgieff
We studied 30 male patients in the early postoperative period to assess the
efficacy, safety and feasibility of a patient-demand, target- controlled
infusion (TCI) of remifentanil. All patients received the same TCI-based
propofol-remifentanil anaesthetic for elective orthopaedic surgery. At the
end of surgery, infusion of remifentanil was reduced progressively until
patients were breathing spontaneously. After extubation and transfer to the
post-anaesthesia care unit, patients were given control of a hand-set and
were able to increase the target remifentanil blood concentration by
increments of 0.2 ng ml-1. If there were no demands, the TCI controller
automatically reduced the target concentration. Pain scores, sedation
level, ventilatory frequency, oxygen saturation and nausea were assessed.
Mean time to onset of satisfactory analgesia (VAS < or = 3, out of 10)
was 18.9 (95% confidence interval (Cl) 15.8-21.9) min at a mean target
remifentanil concentration of 2.02 (Cl 1.87-2.16) ng ml-1. There were no
episodes of hypoxaemia and the lowest ventilatory frequency was 9 bpm.
Nausea occurred in 26.6% of patients and 10% vomited. The majority of
patients were only slightly sedated. These results imply an effective tool
without respiratory side effects in the early postoperative period after
anaesthesia using remifentanil as the analgesic component.
CLINICAL INVESTIGATIONS
Patient-maintained remifentanil target-controlled infusion for the transition to early postoperative analgesia
Department of Anaesthesiology, University of Ulm, Steinhovelstrabetae 9, D-89075 Ulm, Germany; Department of Anaesthesia, Glasgow Royal Infirmary, Glasgow
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  N. S. Park, J.-I. Bae, A. W. Park, J. H. Won, and H. S. Lee Safety and Effectiveness of Analgesia with Remifentanil for Percutaneous Transhepatic Biliary Drainage Am. J. Roentgenol., May 1, 2009; 192(5): 1430 - 1433. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Steinlechner, H. Koinig, G. Grubhofer, M. Ponschab, S. Eislmeir, M. Dworschak, and A. Rajek Postoperative Analgesia with Remifentanil in Patients Undergoing Cardiac Surgery Anesth. Analg., May 1, 2005; 100(5): 1230 - 1235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Calderon, A. Pernia, P. De Antonio, E. Calderon-Pla, and L.-M. Torres A Comparison of Two Constant-Dose Continuous Infusions of Remifentanil for Severe Postoperative Pain Anesth. Analg., March 1, 2001; 92(3): 715 - 719. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Fletcher, M. Pinaud, P. Scherpereel, N. Clyti, and M. Chauvin The Efficacy of Intravenous 0.15 Versus 0.25 mg/kg Intraoperative Morphine for Immediate Postoperative Analgesia After Remifentanil-Based Anesthesia for Major Surgery Anesth. Analg., March 1, 2000; 90(3): 666 - 671. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Schraag, M. R. Checketts, and G. N. C. Kenny Lack of Rapid Development of Opioid Tolerance During Alfentanil and Remifentanil Infusions for Postoperative Pain Anesth. Analg., September 1, 1999; 89(3): 753 - 753. [Abstract] [Full Text] [PDF]
|
|