British Journal of Anaesthesia, Vol 81, Issue 2 216-223, Copyright © 1998 by The Board of Management and Trustees of the British Journal of Anaesthesia
G. G. Page, J. S. McDonald and S. Ben-Eliyahu
We have previously shown that the pre- and postoperative administration of
an analgesic dose of morphine attenuated the tumour-enhancing effects of
surgery. This study was undertaken to assess the relative role and
exclusive importance of pre- versus postoperative morphine administration
on neuroendocrine, metastatic, and behavioural outcomes of surgery in
Fischer 344 rats. The natural killer (NK) sensitive mammary adenocarcinoma
cell line, MADB106, was used in a lung clearance assay to assess host
resistance to metastasis. Either morphine or its vehicle was administered
to all rats at three times: (1) 30 min before surgery (8 mg kg-1, in
saline); (2) immediately after surgery in a slow release suspension (SRS, 4
mg kg-1); and (3) 5 h after surgery at the time of tumour cell inoculation
(2 mg kg-1, in SRS). Five surgery groups underwent an experimental
laparotomy with halothane anaesthesia and received either the vehicle at
all three times or morphine in one of four different regimens: before
surgery only, at all three times, after surgery only at times 2 and 3, and
after surgery total at times 2 and 3 with the preoperative dose added at
time 2. Two control groups underwent anaesthesia alone and received either
morphine or the vehicle at all three times. Surgery resulted in a twofold
increase in tumour cell retention, which was significantly attenuated by
all four morphine treatment regimens (P < 0.05). Furthermore, the two
surgery groups that were treated with morphine preoperatively appeared to
derive greater benefit; whereas the preoperatively treated groups exhibited
a 65-70% attenuation of surgery-induced increases in tumour cell retention,
only a 50% attenuation was evident in the two groups treated
postoperatively. Surgery significantly reduced rearing behaviour and
morphine reversed this effect such that most morphine-treated surgery
groups exhibited similar levels of rearing behaviour as was observed in the
unoperated animals throughout the 4-h postoperative observation period.
Morphine treatment also significantly attenuated surgery- induced increases
in plasma corticosterone concentrations assessed at 5 h after surgery. If
such relationships hold in humans, these findings support the suggestion
that the pre-surgical administration of morphine is key in optimizing its
beneficial effects on surgery-induced increases in metastasis.
LABORATORY INVESTIGATIONS
Pre-operative versus postoperative administration of morphine: impact on the neuroendocrine, behavioural, and metastatic-enhancing effects of surgery
College of Nursing, Ohio State University, 1585 Neil Avenue, Columbus, OH, USA 43210; Department of Anaesthesiology, Ohio State University, 1585 Neil Avenue, Columbus, OH, USA 43210; Department of Psychology, Tel Aviv University, Tel Aviv, Israel
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J.-W. Lee, M. M.K. Shahzad, Y. G. Lin, G. Armaiz-Pena, L. S. Mangala, H.-D. Han, H.-S. Kim, E. J. Nam, N. B. Jennings, J. Halder, et al. Surgical Stress Promotes Tumor Growth in Ovarian Carcinoma Clin. Cancer Res., April 15, 2009; 15(8): 2695 - 2702. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Shavit, G. Fish, G. Wolf, E. Mayburd, Y. Meerson, R. Yirmiya, and B. Beilin The Effects of Perioperative Pain Management Techniques on Food Consumption and Body Weight After Laparotomy in Rats Anesth. Analg., October 1, 2005; 101(4): 1112 - 1116. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. L. Logan, S. Lutgendorf, H. L. Kirchner, E. M. Rivera, and D. Lubaroff Pain and Immunologic Response to Root Canal Treatment and Subsequent Health Outcomes Psychosom Med, May 1, 2001; 63(3): 453 - 462. [Abstract] [Full Text] [PDF]
|
|