Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (6)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Allman, K. G.
Right arrow Articles by Young, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Allman, K. G.
Right arrow Articles by Young, J. D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, Vol 81, Issue 2 188-192, Copyright © 1998 by The Board of Management and Trustees of the British Journal of Anaesthesia

LABORATORY INVESTIGATIONS

Effect of L-lysine on nitric oxide production in ovine endotoxaemia

K. G. Allman, A. P. Stoddart and J. D. Young
Nuffield Department of Anaesthetics, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE

Excess production of nitric oxide contributes to the refractory hypotension associated with sepsis and is dependent upon precursor availability, L-arginine. Endothelial uptake of L-arginine by the y+ transporter can be inhibited by another cationic amino acid, L-lysine. This study was undertaken to determine the effects of L-lysine in an anaesthetized ovine model of endotoxaemia in which nitric oxide production is known to be limited by L-arginine availability. The haemodynamic effects of i.v. L-lysine (500 mg kg-1) were compared with those of a known inhibitor of nitric oxide synthase, NG-nitro-L- arginine-methyl ester, L-NAME (25 mg kg-1) and with control animals (n = 6 per group). Serum nitrates, the stable end metabolite of nitric oxide production, were also measured. L-NAME administration caused a significant increase in systemic and pulmonary vascular resistance (P < 0.0001), mean arterial pressure (P < 0.0001) and a reduction in serum nitrate concentrations (P < 0.0001). The administration of L-lysine had no effect on systemic or pulmonary vascular resistance, mean arterial pressure or serum nitrate concentrations. We conclude that the administration of L-lysine does not inhibit nitric oxide production in this model.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.