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British Journal of Anaesthesia, Vol 81, Issue 2 176-179, Copyright © 1998 by The Board of Management and Trustees of the British Journal of Anaesthesia

CLINICAL INVESTIGATIONS

Effects of a low concentration of isoflurane on contrast sensitivity in volunteers

SRJ. Taylor, O. A. Khan, M. L. Swart, G. G. Lockwood and J. G. Jones
University Department of Anaesthesia, Addenbrooke's Hospital, Cambridge, CB2 2QQ; University Department of Anaesthesia, Royal Postgraduate Medical School, London

The effects of 0.15% quasi steady-state end-tidal isoflurane on the contrast sensitivity of five healthy volunteers were investigated by measuring their performance in computer generated letter discrimination tasks. A series of letters were displayed on a computer screen so that the luminance of the letter differed from that of the background. Two protocols were used: in the static protocol, the letter remained displayed on the screen until the subject responded, whereas in the dynamic protocol, the letter was displayed for 1/72 s only. Isoflurane significantly decreased contrast sensitivity in both protocols in all subjects.
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