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British Journal of Anaesthesia, Vol 81, Issue 2 152-154, Copyright © 1998 by The Board of Management and Trustees of the British Journal of Anaesthesia

CLINICAL INVESTIGATIONS

Perioperative pharmacokinetics of transdermal fentanyl in elderly and young adult patients

J. P. Thompson, S. Bower, A. M. Liddle and D. J. Rowbotham
University Department of Anaesthesia, Leicester Royal Infirmary, Leicester, LE1 5WW; Department of Anaesthesia, Royal Victoria Infirmary, Newcastle upon Tyne

The perioperative pharmacokinetics of transdermally-delivered fentanyl were compared in 10 young adult (mean [range] age 32.7, [25-38] yr) and eight elderly (mean [range] age 73.7 [64-82] yr) patients following abdominal surgery. Transdermal fentanyl patches designed to release 50 micrograms h-1 were applied 2 h preoperatively and left in place for 72 h. Plasma fentanyl concentrations were measured by radioimmunoassay during patch application and for 30 h after patch removal. The mean half-time (time for plasma concentrations to double after patch application) was 4.2 h in the younger group and 11.1 h in the elderly group (P < 0.005). Mean maximum plasma concentrations were 1.9 ng ml-1 and 1.5 ng ml-1 in the younger and elderly groups respectively (ns). There were no differences in the time at which maximum plasma concentrations occurred (tmax), elimination half-life after patch removal, or AUC(0-infinity).
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J. P. Thompson and D. J. Rowbotham
Pharmacokinetics of Transdermal Fentanyl
Anesth. Analg., September 1, 2002; 95(3): 781 - 781.
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