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British Journal of Anaesthesia, Vol 80, Issue 5 634-638, Copyright © 1998 by The Board of Management and Trustees of the British Journal of Anaesthesia

LABORATORY INVESTIGATIONS

Effect of isoflurane on release and uptake of gamma-aminobutyric acid from rat cortical synaptosomes

M. Larsen, T. S. Haugstad, J. Berg-Johnsen and I. A. Langmoen
Institute for Surgical Research and Department of Neurosurgery, Rikshospitalet, National Hospital, Oslo, Norway; Department of Neurosurgery, Ulleval Hospital, Oslo, Norway

We have studied the effect of isoflurane on potassium-evoked release and high-affinity uptake of gamma-aminobutyric acid (GABA) in rat cortical synaptosomes. Isoflurane 1.5% and 3% increased calcium- dependent release by 38% and 36% of control values, respectively (P < 0.05). Calcium-independent release was reduced correspondingly by 24% and 26% (P < 0.05). High-affinity uptake of GABA was not affected by isoflurane. The findings of increased synaptic GABA release combined with unaltered uptake suggest that isoflurane increases GABA in the synaptic cleft and thus may enhance inhibition.
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