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British Journal of Anaesthesia, Vol 80, Issue 5 621-627, Copyright © 1998 by The Board of Management and Trustees of the British Journal of Anaesthesia

LABORATORY INVESTIGATIONS

Comparison of the effects of sevoflurane, isoflurane and halothane on rat myocardium

J. L. Hanouz, B. Vivien, P. Y. Gueugniaud, Y. Lecarpentier, P. Coriat and B. Riou
Departement d'Anesthesie Reanimation, Centre Hospitalier Universitaire (CHU), Cote de Nacre, Caen, France; Laboratoire d'Anesthesiologie, Departement d'Anesthesie-Reanimation, CHU Pitie-Salpetriere, Paris, France; Departement d'Anesthesie Reanimation, CHU Edouard Herriot, Lyon, France; Institut National de la Sante et de la Recherche Medicale (INSERM) Unite 451, LOA-ENSTA-Ecole Polytechnique, Palaiseau and Service de Physiologie, CHU de Bicetre, Le Kremlin-Bicetre, France

The effects of sevoflurane on myocardial contraction and relaxation are poorly understood. Therefore, we studied the effects of equianaesthetic concentrations (0.5, 1, 1.5, 2 and 2.5 MAC) of sevoflurane, isoflurane and halothane on inotropic and lusitropic (myocardial relaxation) variables, and post-rest potentiation in rat left ventricular papillary muscles in vitro. Sevoflurane and isoflurane caused comparable concentration-dependent negative inotropic effects which were significantly lower than those induced by halothane (P < 0.05). Sevoflurane and isoflurane did not modify lusitropic variables under low or high load, whereas halothane showed a negative lusitropic effect at high concentrations. Halothane suppressed post-rest potentiation, whereas isoflurane and sevoflurane did not. Post-rest recovery was unaffected by halothane, isoflurane or sevoflurane at any concentration. Thus in rat myocardium, sevoflurane and isoflurane caused comparable negative inotropic effects, had no significant lusitropic effects and did not alter post-rest potentiation, suggesting that they did not significantly modify the functions of the sarcoplasmic reticulum.
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