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British Journal of Anaesthesia, Vol 80, Issue 4 516-518, Copyright © 1998 by The Board of Management and Trustees of the British Journal of Anaesthesia

CASE REPORTS

Anaesthetic management in patients suspected of, or at risk of, having Creutzfeldt-Jakob disease

J. Hernandez-Palazon, J. F. Martinez-Lage, J. A. Tortosa and J. M. Garcia-Cayuela
Department of Anaesthesia, Virgen de la Arrixaca University Hospital, Murcia, Spain; Department of Neurosurgery, Virgen de la Arrixaca University Hospital, Murcia, Spain

We report two young patients who had repeated neurosurgical procedures and who were thought to be at risk of developing Creutzfeldt-Jakob disease (CJD). The first patient had been given a lyophilized dural graft in the course of removal of a cerebellar medulloblastoma 15 yr previously. The second patient had received pituitary-derived growth hormone for treatment of growth hormone deficiency, secondary to a third ventricle teratoma, exised 13 yr earlier. The presence of cerebellar symptoms together with being recipients of growth hormone or dural graft of cadaveric extraction arose suspicion of a diagnosis of CJD in both individuals. Precautions in the anaesthetic and surgical management of these two patients are discussed, and pertinent literature is reviewed briefly.
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