Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (18)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Shichino, T.
Right arrow Articles by Mori, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shichino, T.
Right arrow Articles by Mori, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, Vol 80, Issue 3 365-370, Copyright © 1998 by The Board of Management and Trustees of the British Journal of Anaesthesia

LABORATORY INVESTIGATIONS

Effects of inhalation anaesthetics on the release of acetylcholine in the rat cerebral cortex in vivo

T. Shichino, M. Murakawa, T. Adachi, T. Arai, Y. Miyazaki and K. Mori
Department of Anaesthesia, Kyoto University Hospital, 54 Shogoin-Kawara-cho, Sakyo-ku, Kyoto 606-01, Japan

By analysing the EEG, reticular multi-unit activity and behavioural changes, we have classified general anaesthetics into three groups: central nervous system (CNS) depressant, CNS excitant and epileptogenic agents. Changes in CNS neural activity are associated with alteration in transmitter release. We have attempted to clarify the actions of widely used inhalation anaesthetics, such as isoflurane (CNS depressant), nitrous oxide (CNS excitant) and sevoflurane (epileptogenic) on acetylcholine (ACh) release in the cerebral cortex using brain microdialysis. ACh release was suppressed by isoflurane and sevoflurane in a dose-related manner but recovered on wash-out. There were no significant differences between the effects of sevoflurane and isoflurane at the same MAC values. In contrast, ACh release was enhanced significantly by nitrous oxide. These findings indicate that the response of the cortical cholinergic cells to different anaesthetics reflects their neurophysiological characteristics, that is whether they stimulate or suppress CNS neurones.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Br J AnaesthHome page
T. Shichino, M. Murakawa, T. Adachi, Y. Miyazaki, H. Segawa, K. Fukuda, and K. Mori
Effects of xenon on acetylcholine release in the rat cerebral cortex in vivo
Br. J. Anaesth., June 1, 2002; 88(6): 866 - 868.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
A. Paraskeva, K. Papilas, A. Fassoulaki, A. Melemeni, and G. Papadopoulos
Physostigmine Does Not Antagonize Sevoflurane Anesthesia Assessed by Bispectral Index or Enhances Recovery
Anesth. Analg., March 1, 2002; 94(3): 569 - 572.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
T. Mori, X. Zhao, Y. Zuo, G. L. Aistrup, K. Nishikawa, W. Marszalec, J. Z. Yeh, and T. Narahashi
Modulation of Neuronal Nicotinic Acetylcholine Receptors by Halothane in Rat Cortical Neurons
Mol. Pharmacol., April 1, 2001; 59(4): 732 - 743.
[Abstract] [Full Text]

Home page
 Anesth. Analg.Home page
D. J. Janiszewski, J. L. Galinkin, P. A. Klock, D. W. Coalson, H. Pardo, and J. P. Zacny
The Effects of Subanesthetic Concentrations of Sevoflurane and Nitrous Oxide, Alone and in Combination, on Analgesia, Mood, and Psychomotor Performance in Healthy Volunteers
Anesth. Analg., May 1, 1999; 88(5): 1149 - 1154.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.