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British Journal of Anaesthesia, Vol 80, Issue 3 302-307, Copyright © 1998 by The Board of Management and Trustees of the British Journal of Anaesthesia

CLINICAL INVESTIGATIONS

Glycogen depletion and lactate accumulation in human intercostal muscles after administration of succinylcholine

M. Mizuno and N. H. Secher
The Copenhagen Muscle Research Centre, Nuclear Magnetic Resonance Centre, Department of Medical Biochemistry and Genetics, The Panum Institute and Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

I.m. glycogen content, lactate concentration and staining intensity for glycogen in slow- (ST) and fast-twitch (FTa and FTb) fibres were determined in the external and internal intercostal muscles after thoracotomy. Thirteen patients received a precurarizing dose of a non- depolarizing neuromuscular blocking agent followed by the depolarizing agent, succinylcholine, to facilitate intubation of the trachea (succinylcholine group). Nine patients received pancuronium or gallamine (control group). There were no significant differences in ventilatory functional capacity between the two groups. In the external intercostal muscles, lower i.m. glycogen content was observed in the succinylcholine compared with the control group (P < 0.05). I.m. glycogen was depleted from the FT fibres and in particular from FTb fibres, while little depletion was noted in ST fibres. In both the external and internal intercostal muscles, a higher lactate concentration was observed in the succinylcholine than in the control group (P < 0.05). The results indicate that the use of succinylcholine for tracheal intubation stimulated breakdown of i.m. glycogen, particularly in fast-twitch muscle fibres, and caused accumulation of lactate in intercostal muscles.
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