British Journal of Anaesthesia, Vol 79, Issue 3 285-288, Copyright © 1997 by The Board of Management and Trustees of the British Journal of Anaesthesia
J. E. Hall, T. A. Oldham, JIM. Stewart and M. Harmer
We have examined the differences in ventilatory characteristics between
halothane and sevoflurane when used for adult vital capacity induction of
anaesthesia. The study was conducted in a randomized, double-blind manner.
After 13 patients had been enrolled, the study was curtailed because the
blinded observer thought that there was an unacceptably high incidence of
adverse events. After the randomization code was revealed, the adverse
events were found to be in the halothane group. Although the sample size
was small, minute volumes appeared to be maintained in the sevoflurane
group. Ventilatory frequencies were similar in the two groups after
insertion of the laryngeal mask airway, but tidal volumes were
significantly greater in the sevoflurane group (P = 0.0013).
CLINICAL INVESTIGATIONS
Comparison between halothane and sevoflurane for adult vital capacity induction
Department of Anaesthetics and Intensive Care Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN
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