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British Journal of Anaesthesia, Vol 79, Issue 3 285-288, Copyright © 1997 by The Board of Management and Trustees of the British Journal of Anaesthesia


CLINICAL INVESTIGATIONS

Comparison between halothane and sevoflurane for adult vital capacity induction

J. E. Hall, T. A. Oldham, JIM. Stewart and M. Harmer
Department of Anaesthetics and Intensive Care Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN

We have examined the differences in ventilatory characteristics between halothane and sevoflurane when used for adult vital capacity induction of anaesthesia. The study was conducted in a randomized, double-blind manner. After 13 patients had been enrolled, the study was curtailed because the blinded observer thought that there was an unacceptably high incidence of adverse events. After the randomization code was revealed, the adverse events were found to be in the halothane group. Although the sample size was small, minute volumes appeared to be maintained in the sevoflurane group. Ventilatory frequencies were similar in the two groups after insertion of the laryngeal mask airway, but tidal volumes were significantly greater in the sevoflurane group (P = 0.0013).
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