British Journal of Anaesthesia, Vol 79, Issue 1 88-96, Copyright © 1997 by The Board of Management and Trustees of the British Journal of Anaesthesia
W. Schlack, B. Preckel, H. Barthel, D. Obal and V. Thamer
In addition to having anti-ischaemic effects, halothane can protect
isolated rat hearts and isolated cardiomyocytes against reperfusion injury
of the "oxygen paradox" type. The aim of this study was to investigate if
halothane can also protect against myocardial reperfusion injury in vivo.
Twenty-two rabbits anaesthetized with alpha- chloralose underwent 30 min of
occlusion of a major coronary artery and 2 h of subsequent reperfusion.
Seven animals received 1 MAC of halothane for the first 15 min of
reperfusion (halothane group), and eight animals served as untreated
controls (controls group). In seven additional animals, the haemodynamic
effects of halothane were antagonized by an i.v. infusion of noradrenaline
(halothane- noradrenaline group). We measured cardiac output (CO) by an
ultrasonic flow probe around the ascending aorta, left ventricular pressure
(LVP) by a tip manometer and infarct size by triphenyltetrazolium staining.
Baseline LVP was mean 92 (SEM 4) mm Hg and CO was 289 (16) ml min-1. During
coronary occlusion, LVP was reduced to 86 (4)% of baseline and CO to 84
(4)% (similar in all groups). During halothane administration at
reperfusion, LVP declined further to 55 (6)% of baseline and CO to 66 (9)%
(P < 0.05 halothane group vs control group). Noradrenaline prevented the
reduction in LVP (halothane-noradrenaline group 87 (5)% of baseline,
control group 84 (6)% and reduction in CO (halothane- noradrenaline group
89 (5)%, control group 83 (6)%. Infarct size was 49 (6)% of the area at
risk in controls and was reduced markedly by administration of halothane to
32 (3)% in the halothane group (P < 0.05) and to 30 (3)% in the
halothane-noradrenaline group (P < 0.05). Treatment with halothane
during the early reperfusion period after myocardial ischaemia protected
the myocardium against infarction in vivo, independent of the haemodynamic
effect of halothane.
LABORATORY INVESTIGATIONS
Halothane reduces reperfusion injury after regional ischaemia in the rabbit heart in vivo
Institut fur Klinische Anaesthesiologie and Physiologisches Institut I, Heinrich-Heine-Universitat Dusseldorf, Dusseldorf, Germany
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