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British Journal of Anaesthesia, Vol 79, Issue 1 3-8, Copyright © 1997 by The Board of Management and Trustees of the British Journal of Anaesthesia

CLINICAL INVESTIGATIONS

Ropivacaine 0.75% for extradural anaesthesia in elective caesarean section: an open clinical and pharmacokinetic study in mother and neonate

CPJ. Morton, S. Bloomfield, A. Magnusson, H. Jozwiak and J. H. McClure
Department of Anaesthetics, Royal Infirmary of Edinburgh NHS Trust, Lauriston Place, Edinburgh EH3 9YW; Department of Neonatal Paediatrics, Royal Infirmary of Edinburgh NHS Trust, Lauriston Place, Edinburgh EH3 9YW; Astra Pain Control AB, Sodertalje, Sweden

In an open study we have investigated the efficacy of 20 ml of 0.75% ropivacaine (7.5 mg ml-1) to provide extradural anaesthesia for elective Caesarean section. Plasma concentrations (total and free) were estimated in the mother and neonate. Anaesthesia was effective and safe. Plasma concentrations of ropivacaine in the mother and neonate were within safe limits and consistent with previous studies. Two mothers received accidental i.v. injections of ropivacaine 75 mg and 150 mg, respectively, without serious adverse effects.
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