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British Journal of Anaesthesia, Vol 79, Issue 1 128-130, Copyright © 1997 by The Board of Management and Trustees of the British Journal of Anaesthesia

SHORT COMMUNICATIONS

Effects of ketamine and pentobarbitone on acetylcholine release from the rat frontal cortex in vivo

T. Kikuchi, Y. Wang, H. Shinbori, K. Sato and F. Okumura
Department of Anesthesiology, Yokohama City University School of Medicine, Yokohama 236, Japan

We have studied the effects of ketamine and pentobarbitone on acetylcholine (ACh) release from the rat frontal cortex using microdialysis. Ketamine 25, 50 and 100 mg kg-1 increased ACh release from the frontal cortex to 286%, 253% and 381% of basal release, respectively. In contrast, pentobarbitone 10, 20 and 40 mg kg-1 caused 73%, 78% and 96% inhibition of basal levels, respectively. The results suggest that ketamine and pentobarbitone have opposite effects on ACh release from the rat frontal cortex, as seen previously in the rat hippocampus.
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