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British Journal of Anaesthesia, Vol 79, Issue 1 125-127, Copyright © 1997 by The Board of Management and Trustees of the British Journal of Anaesthesia

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Dystrophin deficient mdx muscle is not prone to MH susceptibility: an in vitro study

N. Mader, H. Gilly and R. E. Bittner
Institute of Anatomy, Neuromuscular Research Department, University of Vienna, Waehringerstraße 13, A-1090-Vienna, Austria; Department of General Anaesthesia and Intensive Care Medicine (B), University of Vienna and L. Boltzmann Institute for Experimental Anaesthesia and Research in Intensive Care Medicine, A-1090-Vienna, Austria

The association between malignant hyperthermia (MH) and neuromuscular disorders is controversial. An association between MH and Duchenne muscular dystrophy, a common and lethal disorder caused by deficiency of dystrophin, has been reported sporadically but is still not proved. To examine this problem, we performed halothane and caffeine in vitro contracture tests on skeletal muscles from dystrophin deficient mdx mice, an animal model for human Duchenne muscular dystrophy. As neither halothane nor caffeine triggered abnormal responses in mdx muscles, we conclude that dystrophin deficiency per se is not the primary cause of MH-like crises, as reported for patients with Duchenne muscular dystrophy.
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