British Journal of Anaesthesia, Vol 78, Issue 6 748-750, Copyright © 1997 by The Board of Management and Trustees of the British Journal of Anaesthesia
D. Benhamou, J. Hamza, J. J. Eledjam, P. Dailland, M. Palot, J. Seebacher, D. Milon and K. Heeroma
We have assessed the dose-response relationship of a solution of
ropivacaine 2 mg ml-1, given as a continuous extradural infusion to women
in labour. A total of 133 parturients were allocated randomly to one of
four groups to receive a fixed rate ropivacaine infusion of 4, 6, 8 or 10
ml h-1 with additional bolus doses as necessary. Contraction pain, quality
of analgesia, sensory block, motor block and neonatal Apgar scores were
assessed. There were no significant differences between groups in terms of
analgesia or motor block, although significantly more bolus doses were
required by the group receiving 4 ml h-1 (P < 0.05 compared with the
other groups), and a significantly higher total dose of ropivacaine was
administered to the 10-ml h-1 group compared with the 6-ml h-1 group (P =
0.044). There were no significant differences between groups in terms of
obstetric or neonatal outcome. We conclude that ropivacaine 2 mg ml-1 was
effective and well tolerated when given as a continuous extradural infusion
at 6- 8 ml h-1 and may be used as the sole analgesic during labour.
SHORT COMMUNICATIONS
Continuous extradural infusion of ropivacaine 2 mg ml-1 for pain relief during labour
Hopital Antoine-Beclere, Departement Anesthesie, 157 rue de la Porte-de-Trivaux, F-92141 Clamart Cedex, France; Hopital Saint Vincent de Paul, Departement Anesthesie, 74 Avenue Denfert Rochereau, F-75014 Paris, France; Centre Gaston Doumergue, Departement Anesthesie, CHU de Nimes, 5 rue Hoche, F-30006 Nimes, France; Groupe Hospitalier Cochin, Departement Anesthesie, 27 rue du Faubourg St Jacques, F-75014 Paris, France; Hopital Robert Debre, CHRU de Reims, Rue Alexis Carrel, F-51092 Reims, France; Hopital Pitie-Salpetriere, Departement Anesthesie, 47-83 Boulevard de l'hopital, F-75013 Paris, France; Hopital Sud, Departement Anesthesie, 16 Boulevard de Bulgarie, F-35056 Rennes, France; Astra Pain Control, Sodertalje, Sweden
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