British Journal of Anaesthesia, Vol 78, Issue 3 326-327, Copyright © 1997 by The Board of Management and Trustees of the British Journal of Anaesthesia
T. Marx, G. Froeba, D. Wagner, S. Baeder, A. Goertz and M. Georgieff
In order to investigate haemodynamic response and catecholamine release
during anaesthesia with xenon, we conducted a study on 28 pigs which were
allocated randomly to one of four groups: total i.v. anaesthesia with
pentobarbitone and buprenorphine, and xenon anaesthesia with inspiratory
concentrations of 30%, 50% or 70%, respectively, supplemented with
pentobarbitone. Haemodynamic variables were measured using arterial and
Swan Ganz catheters. Depth of anaesthesia was monitored using spectral edge
frequency analysis. Plasma concentrations of dopamine, noradrenaline and
adrenaline were measured by high pressure liquid chromatography. All
haemodynamic variables and plasma concentrations of dopamine and
noradrenaline remained within normal limits. Adrenaline concentrations were
reduced significantly in all groups. Xenon anaesthesia was associated with
a high degree of cardiovascular stability. Significant reduction in
adrenaline concentrations at inspiratory xenon concentrations of 30% and
50% can be explained by analgesic effects of xenon below its MAC value.
SHORT COMMUNICATIONS
Effects on haemodynamics and catecholamine release of xenon anaesthesia compared with total i.v. anaesthesia in the pig
University of Ulm, Universitaetsklinik fuer Anaesthesiologie, Postfach 3880, 89070 Ulm, Germany
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